http://mendel1885.blog.sohu.com/2413055.html

   本人实在难以相信，如此光明正大的实验，在中国，竟然会因为方肘子那个白痴以及它的信誉死亡站，而被莫名冠以“伪科学”“彻头彻尾的造假“的结论。难道中国的科研事业真要靠方肘子这个过期的科学扔货来”监督“吗？

   魏这篇上个月的 文章，近一步证实和完整了异源免疫治疗肿瘤的观点。有这样的文章，以及世界上其他实验室的文章，我支持魏于全就是不拿岀当初原始实验记录：气死那帮白痴

   最后，我要给方肘子及其走狗们一个问题：魏文这个图中的肿瘤体积为何和以前魏文肿瘤体积大不一样？是不是这篇魏文给你们提供魏在NM一文造假的证据？白痴们，回家慢慢想。

   Clin Cancer Res. 2006 Mar 15;12(6):1813-9. Related Articles, Links

   Immunotherapy of tumors with protein vaccine based on chicken homologous Tie-2.

   Luo Y, Wen YJ, Ding ZY, Fu CH, Wu Y, Liu JY, Li Q, He QM, Zhao X, Jiang Y, Li J, Deng HX, Kang B, Mao YQ, Wei YQ.

   State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, People's Republic of China.

   PURPOSE: Tie-2 is an endothelium-specific receptor tyrosine kinase known to play a key role in tumor angiogenesis. The present study explores the feasibility of immunotherapy of tumors by using a protein vaccine based on chicken Tie-2 as a model antigen to break the immune tolerance against Tie-2 in a cross-reaction between the xenogeneic homologous and self-Tie-2. EXPERIMENTAL DESIGN AND RESULTS: In this study, a chicken homologous Tie-2 protein vaccine (chTie-2) and a corresponding mouse Tie-2 vaccine as a control were prepared and the antitumor effect of these vaccines was tested in two tumor models (murine B16F10 melanoma and murine H22 hepatoma). Immunotherapy with chTie-2 was found effective in two tumor models. Autoantibodies against mouse Tie-2 were detected in sera of mice immunized with chTie-2 through Western blot analysis and ELISA assay. Anti-Tie-2 antibody-producing B cells were detectable by ELISPOT. Histologic examination revealed that autoantibodies were deposited on the endothelial cells of tumor tissues. Purified immunoglobulins from chTie-2-immunized mice could induce the apoptosis of human umbilical vein endothelial cells in vitro. Importantly, adoptive transfer of purified immunoglobulins led to antitumor effect in vivo; apparently, angiogenesis was significantly inhibited in these tumors. Furthermore, the antitumor activity and production of autoantibodies could be abrogated by depletion of CD4+ T lymphocytes. CONCLUSIONS: Our findings may provide a vaccine strategy for cancer therapy and show the potential utilization of interference with Tie-2 pathway.

   日本人的这篇文章，引用了魏的文章，基本重复了魏文关于人脐带静脉內皮细胞HUVEC免疫老鼠，可以抑制肿瘤生长的实验，更重要的是，日本人也声称是inhibits angiogenesis.基本确认了魏文的实验结论。不同的是，他们也用了老鼠肝脏的內皮细胞HSE免疫，发现也有抑制肿瘤生长的功能，他们并认为HSE的免疫效果比HUVEC还要好点。另外，他们没有用免疫佐剂。也就是说，在没有免疫佐剂的情况下，魏文的结论也是成立的。

   方傻恐怕要说了，这些日本人是魏于全的同伙骗子。